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According to this, L-leucine, L-isoleucine and L-methionine are better substrates for cellular efflux than influx to the cell (Fotiadis et al., 2013)
The interaction between ligand and receptor proteins triggers intracellular responses involving proteins such as NF- (Rickert et al., 2011), and JNK (MacFarlane et al., 1997)
In conclusion, understanding the intricate interplay between epigenetic modifications and drug resistance is critical in cancer treatment

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An updated review on the role of small molecules in mediating protein degradation
