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238 In effect, the PI3K/AKT/mTOR pathway ensures that CSCs have sufficient macromolecules to support their basal uptake and maintenance of their stem cell properties

Hum Mol Genet 14:R139R147 Weitzman SA, Turk PW, Milkowski DH, Kozlowski K (1994) Free radical adducts induce alterations in DNA cytosine methylation

TP73 expression rises by 938%, USP29 (which stabilizes the critical p53 tumor suppressor) jumps 1,056%, and BRCA1 and PTEN both see significant upregulation

In experimental spinal cord injury models, GLPs preserve myelin ultrastructure and enhance functional recovery through multimodal neuroprotective actions: they suppress neuronal and oligodendroglial apoptosisevidenced by reduced caspase-3 cleavageattenuate neuroinflammation via downregulation of TNF- and myeloperoxidase (MPO) activity, and counteract oxidative damage by decreasing MDA and NO levels while boosting SOD activity