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Lactylation, which occurs in response to heightened lactate concentrations, is intricately connected with the pathogenesis and progression of CVD

This may be attributed to the downregulation of the other Cyp genes ( CypD and CypG) , which when silenced together with CypB may contribute to more drastic effects on interactions with other genes, misregulation in their cumulative roles in correct folding of proteins and more drastic phenotypes as we observed

doi:10.1038/sj.mp.4000805 11

This makes it loosely bound to Insulin-like Growth Factor Binding Proteins (IGFBPs)

[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Duarte P., Cuadrado A., Len R

Jacobs W, Lammens M, Kerckhofs A, Voets E, Van San E, Van Coillie S, et al