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Thus, new theories about the pathophysiology of depression and the action of antidepressant treatment proposes that mood disorders are caused by structural or functional changes in particular molecules and signalling pathways in the brain, and that antidepressants function by counteracting these molecular changes

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Since their first report in 1990, SELEX technology has been continuously improved, 174,175 diversifying the selection and development of high-affinity aptamers

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However, they are affected by different animal sources and batches, have poor reproducibility, are relatively sensitive and have harsh cultural conditions

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