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GH levels decline approximately 14% per decade after age 30, and this decline contributes to loss of lean mass, increased body fat, reduced bone density, impaired recovery, and diminished skin quality
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Cells (2021) 10(3):639

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Specifically, modulation of macrophage polarization through inhibition of the TGF-/Smad3 pathway has been demonstrated to reduce collagen deposition in the kidneys of diabetic rodents (23)
