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Among these, pDCs do not bind conidia but enhance the oxidative burst to boost conidial killing in neutrophils ( Figure 1 Certainly, there are many other disease-causing pathogens in CAP, but the same is true for the various immune responses of the organism to pathogens, which are usually beneficial to the host ( The new idea holds that the various microorganisms in the lungs have a complex relationship with the host and with each other that is analogous to an adaptive island', where they maintain a dynamic equilibrium and constraints ( Compared with healthy young adults, it is commonly agreed that older adults have characteristic elevated serum levels of proinflammatory markers ( 3 Overview of oxidative stress Oxidation and antioxidation are two systems in the body that are interdependent but also mutually restrictive, and oxidative stress is the result of a disruption of the pro-oxidantantioxidant balance and the consequent accumulation of ROS ( Fortunately, the innate cellular antioxidant system also blocks overly intense inflammatory responses and prevents excessive ROS accumulation, thus limiting damage and inhibiting disease ( glutathione (GSH), coenzyme Q10 (CoQ10), and melatonin, and non-naturally produced antioxidants, such as vitamin C (VitC), vitamin E (VitE) and flavonoids ( glutathione peroxidase (GPX), glutathione S-transferase and glyoxalase ( catalase (CAT), superoxide dismutase (SOD), GPX, etc