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Secondly, plasma concentrations of tritiated ergothioneine were reported to increase in response to oral administration of ergothioneine in SLC22A4 knockout mice, albeit not as highly as in wild-type mice (35)

This was confirmed by Cantara et al

20 In addition to curcumin, several phytochemical substances, including M

Epithelial cellextracellular matrix interactions and stem cells in airway epithelial regeneration

This effect was not observed when either drug was administered alone, suggesting a synergistic mechanism

Despite lower systemic absorption, it maintains local activity in the gut , offering significant benefits for: Ulcers and acid damage Leaky gut and intestinal inflammation NSAID-induced GI injury Key features: Shorter systemic half-life (~24 hours) Strong local effect on gastric mucosa Best used for digestive repair and mucosal protection Which Clears Faster