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Upon the release of zonulin into the lumen as a result of intestinal exposure to gliadin, zonulin can interact with two receptors, epidermal growth factor receptor (EGFR) and protease-activated receptor 2 (PAR2), which results in increased intestinal permeability (27, 32)

doi: 10.3389/fpsyt.2022.933704 71

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The mechanistic and animal-model data for AOD9604 are relatively mature compared with many newer peptides, given the compound's formal drug-trial history

Li S, Jiang H, Wang B, Gu M, Zhang N, Liang W, et al

Front Nutr 10:1136458
