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Ehlers-Danlos Syndrome (EDS) encompasses a group of genetic connective tissue disorders marked by joint hypermobility, easily bruised skin, and tissue fragility

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It should be stressed that only part of the variance in Long COVID somatic and mental symptoms was explained by IO&NS pathways indicating that other mechanistic processes are involved

In PD patients, reduced BH4 levels and GCH1 activity in the SN and striatum are associated with PD progression, indicating that aberrant BH4 metabolism contributes to PD pathogenesis (105)

: "Is Cognitive Impairment in Cirrhotic Patients Due to Increased Peroxynitrite and Oxidative Stress?" in: Antioxidants & redox signaling , (2015) (PubMed)

Briefly, the recognition of SECIS by the translational machinery results in the recruitment of specific translational factors that decode in-frame UGA codons by inserting selenocysteine into elongating selenoproteins (4)
