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Die in der systematischen bersichtsarbeit und Metaanalyse ermittelte analgetische Wirkung knnte demnach hnlich gro sein, wie sie auch unter klassischen Schmerzmitteln erzielt wird

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Published Phase 2 data has demonstrated dose-dependent metabolic effects in clinical research

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Granulocytemacrophage colonyforming cells treated with macrophage colonystimulating factor show increased PKC levels and stimulated its translocation to the nucleus, leading to macrophage differentiation.73 Similarly, hexamethylenebisacetamideinduced differentiation of Friend erythroleukaemia cells requires the localization of PKC to the nucleus as PKC antisense transfection prevented cell differentiation.74 Also, the translocation of specific PKC isoforms is dependent on the stimulus used within the same cells.75 This can be seen in human promyelocytic leukaemia HL60 cell line, where vitamin D3 exposure leads to increased levels of PKC isoform while anti trans retinoic acid treatment leads to an increase in PKC and PKC isoform in the nucleus.76, 77 In contrast, HL60 cells stimulated with PMA leads to the accumulation of PKC within the nucleus.78 As mentioned earlier, PKC is activated by second messengers generated from immune cell activation such as calcium and/or DAG depending on the PKC isoform