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According to the 2022 Guide for Diagnosis, Treatment, and Health Management of Benign Prostatic Hyperplasia published in China, BPH affects nearly 20% of men aged 5160 years, increasing to 50% in the 6170 age group and culminating in an astonishing 83% prevalence among those aged 8190 years (Wang et al., 2022)

Upon activation by TGF-, this pathway involves the phosphorylation of Smad2 and Smad3, their association with Smad4, and subsequent nuclear translocation of the complex to regulate gene expression that favors M2 polarization (255)

Maternal plasma folate, vitamin B12 levels and multivitamin supplementation during pregnancy and risk of Autism Spectrum Disorder in the Boston Birth Cohort. The FASEB Journal 30 (2016): 151-6

doi: 10.1111/j.1524-4725.2005.31728

Alcoholism: Clinical and Experimental Research, 33 (9), 1489- 1507.