drug causes cysteine starvation glutathione depletion mrc5 Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis CHAC1 degradation of glutathione enhances

Mechanistic investigation revealed ChaC1/AUR-driven cytotoxicity was attenuated by disulfide reducing agents (e.g., NAC and TCEP), while maintaining resistance to canonical programmed death pathway inhibitors targeting apoptosis, necroptosis, and ferroptosis

Glutathione exists within every single cell of the body

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