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otherwise, the score was attributed as zero (0)

Furthermore, as highlighted in the previous section regarding therapeutic strategies, the critical relationship between immunosenescence and inflammation has prompted clinical trials to investigate targeting macrophages (NCT01045512), endothelial cells (NCT04537884), and neutrophils (NCT02441205) (Table 2) in an effort to mitigate immunosenescence and combat conditions such as congestive heart failure, neovascular age-related macular degeneration, and diabetes

Protective effects of auricularia auricular polysaccharide on chronic cerebral ischemia injury in rats

Moreover, knockdown of HMGB1 or S1R, as well as overexpression of Sirt6, alleviates diabetic nephropathy by regulating the NRF2 pathway, indicating the potential of NRF2 as a research target [61, 128, 129]

A cross-sectional study involving 811 welders exposed to Mn fumes found a significantly higher prevalence of Parkinsonism compared to a reference group (Racette et al., 2012)

Validation of Interaction Specificity The specificity of protein interactions is critical for reliable biological interpretations