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Savino F, Fissore MF, Grassino EC, Nanni GE, Oggero R, Silvestro L

Food and Chemical Toxicology, 50, 20272033

Plant Physiol Biochem 210:108564

In IBD, the expression levels of tight junction proteins such as ZO-1 and Occludin, is generally suppressed, leading to increased intestinal permeability, enhanced pathogen infiltration, and exacerbated inflammatory responses (Dong et al., 2022)

To assess treatment response, the study uses advanced imaging tools including intestinal ultrasound (IUS) and magnetic resonance enterography (MRE)

NCR has been described to respond to glutamine and glutamate deficiencies through the activation of Gln3 or Gat1 respectively, while ammonium is considered a distinct signal for NCR that acts independently of the glutamine and glutamate levels [34]