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Inositol supports insulin signalling pathways, while carnitine supports mitochondrial energy production they address different aspects of metabolic health and are complementary rather than redundant

Patients experiencing significant gastrointestinal side effects may benefit from temporary dose reduction or slowing the titration schedule

doi: 10.1046/j.1523-1755.1999.00273.x

Therefore, this review elucidates the etiology, inducements, pathogenesis and treatment modalities of migraine, the clinical evidence that migraine is associated with oxidative stress and neurogenic inflammation, as well as the experimental evidence of antioxidant and anti-inflammatory effects of topiramate, which is of great significance for further research and exploration of the possible mechanisms of topiramate in the treatment of migraine by modulating oxidative stress and neurogenic inflammatory pathways

Cellular uncoupling induced by accumulation of long-chain acylcarnitine during ischemia