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That is, short peptides probably modulate neurodegenerative processes at the epigenetic level, thus contributing to the improvement of cognitive functions in the AD and constituting the cornerstone of neuroprotection

The arc from an encouraging 12-week readout to a null 24-week pivotal result is a textbook example of that shrinkage, and it is a pattern seen across the metabolic-drug field, not a quirk of this peptide

doi: 10.1128/mBio.00722-20

Br J Pharmacol 140(2):305314 Von Lubitz DK, Lin RC-S, Popik P, Carter MF, Jacobson KA (1994) Adenosine A3 receptor stimulation and cerebral ischemia

R., Martins, M

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