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This pain syndrome is thought to be caused by perineural fibrosis of the interdigital nerves (Fig

The main challenges include overcoming financial and regulatory issues, especially for agents targeting hematological malignancies

References Hsieh MJ, et al
Pregnancy and breastfeeding are also contraindications due to insufficient safety data

This allows for sustained analysis without requiring daily administration, making Trinity-X ideal for longitudinal research protocols

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