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It has also been suggested that CRP is capable of recognizing both self- and foreign molecules based on pattern recognition, something that other activators, like IgG, cannot achieve as immunoglobulins recognize solely distinct antigenic epitopes [80]

It also acts as a skin conditioning agent

Those with an inherited cause are more likely to develop melanoma when younger with a median age of 3345 Hormones - the use of use of unopposed oestrogen therapy in HRT might increase the risk of melanoma, there is no evidence for an increased risk in combined HRT