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While these DMVs are generally believed to be formed via viruses manipulating the endoplasmic reticulum (ER) membrane, the mechanism for importing and packaging proteins and RNA into these miniature organelles is not clearly understood [68]

The non-motor symptoms of PD include autonomic, psychiatric, sensory and cognitive impairments, as well as dementia 1

Iron acts as a cofactor in the production of ROS and hastens oxidative damage that attacks cellular DNA, proteins, and membranes, especially the internal mitochondrial membrane where the electron transport chain reaction takes place 84

This suggests a potential role for ferroptosis in tumor immunotherapy