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Accelerated ageing is linked to the lower expression of transcripts encoding various proteins of the repair system (Ciacka et al

Simultaneously, long-chain acyl-CoA synthetase 4 (ACSL4) expression decreases, reducing the availability of oxidizable PUFAs, although the exact mechanism underlying this remains unclear

In vitro , they found that NNMT knockdown and NNMT inhibition by MNA both significantly increase the oxygen consumption in adipocytes

These studies suggested that high levels/activities of TrxR were correlated with melanin formation, providing additional information on the roles of cellular antioxidant proteins in melanogenesis (Table 1)