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& Dunne, J

The primary endpoint was change in body weight and body composition over 12 weeks of treatment

Importantly, mutant SOD1 has been demonstrated to decrease the expression of antioxidant transcription factor NRF2 and its dependent target genes in an established NSC134 cellular model for SOD1-associated ALS (Kirby et al., 2005)
Sci Rep 8 , 8426 (2018)

[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Batchelor EK, Kapitsinou P, Pergola PE, Kovesdy CP, Jalal DI

These biomarkers should be evaluated in the clinic
