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10.1016/S0021-9258(19)45228-9 186 MohantyJ

Concurrently, the nanoreactors also activate the systemic immune system in mice, preventing tumor metastasis and recurrence

Emerging molecular methods, especially single cell sequencing technologies, are revolutionizing our ability to clarify mechanisms underlying MASLD-associated fibrosis and HCC

Several mechanisms have been proposed to explain this: (i) bystander apoptosis occurs due to viral proteins promoting the apoptosis of nearby cells (notably HIV-1 gp120 after its interactions with CD4+ and CCR5 or CXCR4 coreceptors), (ii) immune activation induces FasL production and Fas (CD95) expression in nearby, uninfected CD4+ T cells, resulting in shortened lifespans and an increased sensibility to activation-induced cell death (AICD), and (iii) abortive infection leading to pyroptosis through the caspase-1 pathway, due to an accumulation of incomplete reverse transcripts and the induction of antiviral and inflammatory responses [11]

The main project is the AltDSS engine/DSS C-API library, a customized port of the original/upstream OpenDSS source code, exposed with a more traditional C API