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In this comment, we present major concerns and possible solutions in cell therapy for disc degeneration (Table 2)

Sometimes, these substances are essentially bootleg versions of approved drugs, like semaglutide, but are procured for a fraction of their market price from dealers online

Before we dive into the science of the fluids, we need to clear up some confusion about terminology

This mitochondrial injury promotes the release of apoptotic mediators like cytochrome c and caspases, initiating programmed cell death

The study highlights that oxidative stress is not merely a byproduct of these illnesses, but a core, shared mechanistic driver of the pathology

JOR Spine 1 , e1036 (2018)