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However, both Orbitrap and FT-ICR are limited by high operating costs and long analysis times in the ultra-high-resolution mode

10.1016/j.celrep.2020.108421 153 ShiT.MaY.CaoL.ZhanS.XuY.FuF.et al (2019)

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It is now clear that melanocytic nevi constitute benign neoplasms of cutaneous melanocytes, which frequently harbour oncogenic serine/threonine-protein kinase B-Raf (BRAF) or, less commonly, neuroblastoma ras viral oncogene homolog (NRAS) mutations

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Cost analysis from June 2022 indicates that a clinically effective dose of ALC (2000 mg/day) costs patients $27.60 monthly