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& Zou, B
It begins with diagnosis, inflammatory control, mechanical load strategy, and tissue-specific priorities
Their mechanism of action involves several facets: initially, they inhibit the production and release of inflammatory mediators such as prostaglandins, leukotrienes, and tumor necrosis factor, which are pivotal in the pathogenesis of DED (Sheppard et al., 2013)
These mechanisms range from molecularlevel sensitization in the periphery and central nervous system (CNS) to largescale remodeling of brain circuits, culminating in distinct clinical phenotypes classified as nociceptive, neuropathic, or nociplastic pain
New approaches such as nanomedicine approaches, photodynamic therapy may be effective in solving these problems
doi: 10.1016/j.biortech.2009.01.080
