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SIBO has been associated with dysfunctional intestinal motility, characterized by inadequate peristaltic action of gastrointestinal smooth muscle (171174), hypochlorhydria, and pancreatic exocrine insufficiency (175)

doi: 10.1016/j.atherosclerosis.2010.07.015

R.SharpeA.McGregorL.BekkaouiD.et al

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Regarding IGF-1R TKIs, three separate phase I/II clinical studies have evaluated the safety and efficacy of BMS-754807 in combination with paclitaxel plus carboplatin in patients with advanced solid tumors (NCT00793897), and with either trastuzumab (an HER-targeted mAb) or letrozole in patients with breast cancer (NCT00788333