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Attack on DNA may trigger cell apoptosis or gene mutation, affect the normal proliferation and differentiation of thyroid cells, further damage the synthesis and secretion of thyroid hormone, and eventually aggravate the hypothyroidism condition (Lushchak, 2014)

This response includes the activation and localization of neutrophils which play their role by utilizing their respiratory burst pathways in which oxygen is converted to a singlet oxygen and then to a hydrogen peroxide molecule and hypochlorite which results in death of the bacteria

Promote angiogenesis the growth of new blood vessels, improving nutrient delivery to damaged tissue, particularly helpful with wounds

doi: 10.3109/08923979909016395 52 DsouzaAJDesaiSDRudnerXLKellyMNRuanSShellitoJE

The ligand epothilone 3D structure was retrieved from the PubChem database and prepared by the energy minimization in Chimera