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In contrast to other GPxs, GPx4 is the only one that reduces the hydroperoxides of lipoproteins and complex lipids, such as cholesterol, cholesterol esters, and phospholipids [108], to protect mitochondrial ATP generation from oxidative damage [109]

This leakage further activates microglia towards the M1 phenotype, promoting release of neurotoxic agents, including TNF- and IL-6 (50)

51 Other natural and synthetic molecules could also be good candidates for DNMT inhibitors

The rotary machine in the cell, ATP synthase.J Biol Chem 2001;276(3): 1665-1668

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Then, we make some classifications of GSH-responsive and -exhausting metal nanomedicines used in cancer therapy, including inorganic nanomaterials, metal-organic frameworks (MOFs), and platinum-based nanomaterials