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In addition to being useful in diagnosing low thyroid in patients, SHBG can also be used to determine the optimal replacement dose or preparation (T4, T4/T3 vs straight T3)

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Cytokines and inflammatory markers, including tumor necrosis factor-alpha (TNF-) and interleukins 1 or 6 (IL-1, IL-6), further indicate the level of hepatocyte-macrophage apoptosis (Hu et al., 2025)