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Critical safety considerations for laboratory use include potential immunogenicity concernswith peptide therapeutics commonly showing injection site reactions (20-40% with subcutaneous administration) and possible antidrug antibody formationalong with theoretical concerns that pro-angiogenic properties could potentially influence experimental tumor models, requiring appropriate controls in oncology-related research

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[DOI] [PMC free article] [PubMed] [11].Flory J, Lipska K

6 (2007) 425431, 10.1111/j.1601-183X.2006.00268.x
