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This description applies to a highly heterogeneous spectrum of pain syndromes presenting with a broad range of signs and symptoms, with various underlying pathophysiological mechanisms

TGF- family signaling in connective tissue and skeletal diseases

Moreover, NELL-1 has been shown to enhance BMP-2-induced bone formation while inhibiting BMP-2-induced lipogenesis via the Wnt signaling pathway [423]

Further analysis suggested that the adipose tissues of the AOD 9604 peptide animals had increased lipolytic activity and no marked insulin sensitivity interruption in the animals