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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

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The following day, L1 larvae were transferred to NGM plates at ZT1 and were grown for 48 h to the L4 stage under the same LD/CW cycle

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In vitro studies have demonstrated that autophagy is essential for viability and the clearance of protein aggregates, particularly when proteasomal degradation is compromised [46]

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