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All animal experiments and tissue collection were performed in accordance with the European Communities Council Directive (2010/63/EU) and approved by the local authority, the Lower Saxony State Office for Consumer Protection and Food Safety (Niederschsisches Landesamt fr Verbraucherschutz und Lebensmittelsicherheit) or by the Ethical Committee on Animal Health and Care and the local authority of the State of Saxony-Anhalt, Germany (license numbers: 42502-2-1316 DZNE and 42502-2-1322 DZNE)