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These benefits stem from glutathiones fundamental role in cellular metabolism, its ability to neutralize harmful free radicals, and its crucial involvement in phase II detoxification processes

Several studies have provided evidence on how vitamin D deficiency/supplementation may alter the risk factors associated with the pathogenesis of chronic airway inflammatory and infectious respiratory diseases [4, 5]

All authors contributed to the manuscript revision, read, and approved the submitted version

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In this regard, the concept of treatable traits was defined to identify distinct clinical phenotypes and individualize treatments to achieve the best clinical outcomes in patients with bronchiectasis.16 Several studies have analyzed different systemic and local biomarkers, but only a few of them have demonstrated strong potential (Table 1).16 The vicious cycle hypothesis of bronchiectasis

These effects are well-documented with exogenous GH administration and represent the main metabolic risk of elevated growth hormone levels