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Complications of radiation therapy (e.g., radiation necrosis)

FIGURE 1 Iron metabolism Iron can generate ROS through enzymatic or non-enzymatic reactions

The decreased SAM : SAH ratio leads to an increase in CYP2E1, lipid peroxidation, the upregulation of ER stress marker genes, and prevention of DNA methylation (7679)

Outcome monitoring should employ validated, condition-specific measures appropriate to the treatment indication

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Intranasal treatment with nanoparticles containing thyrotropin-releasing hormone significantly reduced the seizure afterdischarge duration and increased the number of stimulations required to reach a generalized tonicclonic seizure in a kindling model of temporal lobe epilepsy [250]