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[10] Long-term use of proton pump inhibitors (PPIs) and H2-receptor antagonists reduces gastric acid, potentially impairing the release of B12 from dietary proteins

Quick Answer: Dihexa is a synthetic small molecule developed at Washington State University from angiotensin IV research, often called a peptide despite being more accurately described as a peptidomimetic Despite being commonly called a peptide, Dihexa contains chemical modifications that make it more accurately described as a peptidomimetic small molecule

doi: 10.1056/NEJM199605023341802

The animals were treated daily during five weeks with L-NAME (10 mg/kg b.w.), L-arginine (100 mg/kg b.w.), NaBPC157 (10 g/kg b.w.) and their combinations (L-NAME + NaBPC157, L-NAME + L-arginine) intraperitoneally

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M., & Pidoux, M