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387 Pegloticase, a recombinant urate oxidase conjugated to polyethylene glycol (PEG), has been introduced to reduce immunogenicity and extend the half-life of rasburicase

IQGAP3 and IQGAP1 activate ERK-related cell proliferation and function as oncogenes, while IQGAP2 tends to inhibit tumor progression [14, 15]

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