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Clinical trials, or academic or private research projects, are not clinical diagnostic investigations

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[DOI] [PubMed] [Google Scholar] 100.Sikiric P., Separovic J., Buljat G., Anic T., Stancic-Rokotov D., Mikus D., Marovic A., Prkacin I., Duplancic B., Zoricic I., et al

By activating both incretin pathways, tirzepatide enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, delays gastric emptying, and reduces appetite through central nervous system effects

To validate NNMT as an anti-obesity drug target, we investigated the permeability, selectivity, mechanistic, and physiological properties of a series of small molecule NNMT inhibitors