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USA 107 , 1592115926 (2010)
126 The upregulation of IDH1 may represent a common metabolic adaptation for diminishing oxidative stress and supporting macromolecular synthesis, consequently promoting tumor growth and therapy resistance
Xiu et al., 2012)
At least 300 pathogenic mutations in POLG have been defined to date
Why researchers reach for IGF-1 LR3 ~3 IGF-1 potency Reduced IGF-binding-protein affinity keeps more peptide circulating freely - the basis for its enhanced potency relative to native IGF-1
