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These were prolonged QTc intervals [89], gastric lesions, and lower esophageal sphincter and pyloric sphincter dysfunction induced by dopamine receptor antagonists [68,92,165,172], as well as gastric lesions induced by combined application of dopamine receptor antagonist and reserpine [166]

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NNMT is a cytosolic enzyme that catalyzes the methylation of nicotinamide, connecting nicotinamide handling to broader methyl-donor and NAD related pathways