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ALDH2 functions as a potent scavenger of ROS (26)

In this review, we will systematically summarize the recent progress of amino acid metabolism in malignancy and discuss their interconnection with mammalian target of rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth and immunity, and ferroptosis

528 It has improved the quality of eye redness and tear film in human and animal models

We speculate that this phenomenon may be related to temporal factors and cell types

As Lissoni et al works reported, Melatonin is useful in chemotherapy of cancer patient with poor clinical condition [96], advanced cancer patient with normal clinical status [96] and improve the efficacy of anthracyclines, cisplatin, 5fluorourcil, etoposide, gemcitabine, taxanes, raltitrexedand, isofosfamide [96,97].] Melatonin through numerous biological mechanisms is able to influence hosttumor interactions which may change both tumor and host characteristics [98- 100]