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The fixed concentrations of CB-839 used in these studies (up to 1 M for AML (10, 11, 37) and 5 M for multiple myeloma (24) were used without evaluation of the IC 50

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This study adds to this body of work by providing a temporal dimension to proteomic profiling, demonstrating how maturity-dependent protein expression impacts organoid functionality

MRI/MRA revealed restricted diffusion in the left posterior temporal white matter and occlusion of the left M1 of middle cerebral artery (MCA)

A third method involves the stereotactic injection into the brain parenchyma of endothelin-1, a potent vasoconstrictor peptide