epithalon vs gdf11 Rather than a “rejuvenating” agent, may have a detrimental effect on liver senescence. Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy [2021, open-access] : r/longevity Biochemistry and Biology of GDF11
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![epithalon vs gdf11 Rather than a rejuvenating agent, may have a detrimental effect on liver senescence. Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy [2021, open-access] : r/longevity Biochemistry and Biology of GDF11](https://www.ahajournals.org/cms/10.1161/CIRCRESAHA.116.308391/asset/187d597a-20cf-4d39-96e3-ba48bbb69080/assets/graphic/1125fig02.jpeg)
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![epithalon vs gdf11 Rather than a rejuvenating agent, may have a detrimental effect on liver senescence. Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy [2021, open-access] : r/longevity Biochemistry and Biology of GDF11](https://www.mdpi.com/ijms/ijms-24-00421/article_deploy/html/images/ijms-24-00421-g001-550.jpg)
466 CurriuMCarrilloJMassanellaMRigauJAlegreJPuigJet al
![epithalon vs gdf11 Rather than a rejuvenating agent, may have a detrimental effect on liver senescence. Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy [2021, open-access] : r/longevity Biochemistry and Biology of GDF11](https://www.mdpi.com/ijms/ijms-21-02598/article_deploy/html/images/ijms-21-02598-g001.png)
[62] [63] The mechanism of action is straightforward: the hydroxycobalamin hydroxide ligand is displaced by the toxic cyanide ion, and the resulting non-toxic cyanocobalamin is excreted in urine
![epithalon vs gdf11 Rather than a rejuvenating agent, may have a detrimental effect on liver senescence. Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy [2021, open-access] : r/longevity Biochemistry and Biology of GDF11](https://www.cell.com/cms/10.1016/j.cmet.2016.06.017/asset/168a3c4a-9d1d-4547-9294-ac103c777b95/main.assets/gr1_lrg.jpg)
These areas of investigation are of particular relevance
![epithalon vs gdf11 Rather than a rejuvenating agent, may have a detrimental effect on liver senescence. Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy [2021, open-access] : r/longevity Biochemistry and Biology of GDF11](https://ars.els-cdn.com/content/image/1-s2.0-S1550413115002211-gr1.jpg)