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Inhibition of ALDH2 leads to an increase of DOPAL and hence accumulation of THP, which selectively decreased dopamine release and hence led to inhibition of pro-addiction reward signaling through a negative-feedback loop (7, 354)

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this is the reason why GSH is so homeostatic

Laboratory studies in renal function demonstrate that FOXO4-DRI administration restores kidney function in both accelerated aging models and naturally aged mice, indicating that senescent cell elimination can reverse organ-specific age-related deterioration

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