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Therapeutic interventions that target CNS-resident cells have been limited by the challenge of delivering drugs across the BBB, as NTFs pass the BBB only to a limited extent (140, 141)

Compounds with slower reaction rates may require extended time for accurate measurement

The 500 g per day study by Crane et al

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Conversely, iron-chelated lactoferrin inhibits osteoclast-mediated bone resorption by reducing the RANKL/OPG ratio, thereby increasing the bone mineral density (92, 94)

Parasite and disease control is critically dependent on interferon (IFN)-producing type 1 T helper (Th1) cells and macrophages expressing type 2 nitric oxide synthase (NOS2), whereas non-healing, chronic CL has been linked to the expansion of interleukin (IL)-4-secreting Th2 cells, IL-10-producing CD4 + T cells and the expression of arginase 1 (ARG1) (Bogdan et al., 2024