gclc glutathione Down regulation of and glutamate cysteine ligase in the inflammatory response of macrophages Glutamate cysteine ligase and the

*Correspondence: Thorsten Hoppe, [email protected] This article was submitted to Molecular and Cellular Pathology, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Serious Vitamin B12 deficiency can result in decreased number of red blood cells (anemia), stomach or intestinal diseases and permanent nerve damage

Proposed mechanisms include upregulation of growth factor receptors, stimulation of fibroblast migration and collagen synthesis, and promotion of angiogenesis at injury sites

Early treatment offers the best chance of complete recovery, whilst established nerve damage may show only partial improvement despite adequate B12 replacement

& Crowe, T