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Although they provide one source of complexity, the INSR and IGF1R themselves are quite similar, sharing 84% amino acid similarity in the subunit cytoplasmic region, where the tyrosine-specific kinase domain is found, 64-67% similarity in the extracellular subunit region [12], and 100% similarity in the ATP binding domain

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Unlike previous studies that have primarily focused on isolated glycemic markerssuch as HbA1c levels, severe hypoglycemia, or disease durationthis study employs a network-based approach to simultaneously assess the interactions between multiple factors in shaping cognitive function

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The positions of the other equilibria from the redox mobility shift assays in Fig