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10.3389/fnmol.2025.1518868 [DOI] [PMC free article] [PubMed] [Google Scholar] 48.Zhang J, Zhang Y, Wang J, Xia Y, Zhang J, Chen L

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A role for genetic has been demonstrated, with evidence of an increased risk of NAFL in patients with polymorphisms, like those associated to patatin-like phospholipase domain containing 3 (PNPLA3) rs738409, transmembrane 6 superfamily member 2 (TM6SF2) rs58542926 and membrane bound O-acyltransferase domain containing 7 (MBOAT7) rs641738 (4447)

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Recent studies in model systems and humans reveal that ironsulphur proteins have important roles in mitochondrial iron homeostasis and in the pathogenesis of the human disease Friedreich ataxia