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Moravej, H., Moravej, Z., Yazdanparast, M., Heiat, M., Mirhosseini, A., Moosazadeh, M.M., et al., Microb

While some people use high-dose glutathione for its potential to affect melanin production, the evidence for permanent skin lightening is limited and inconsistent

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189 In contrast, from a prophylactic approach, another research group proposed what they deemed a cost-effective approach of yearly injections of 1000 g of vitamin B12 to every patient on metformin to reduce the risk of deficiency and also stated that this could remove the requirement for annual screening, though this has not been empirically tested

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