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B12 is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood
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Preclinical studies report approximately 1.6 increases in intracellular NAD+ following NNMT inhibition in adipocyte models
In human colon cancer cells, silencing NNMT resulted in approximately a 30% increase in NAD + levels (Xie et al., 2014), whereas NNMT overexpression decreased NAD + levels by 30% (Xie et al., 2014)
PMCID: PMC10146734
